A role for epithelial gammadelta T cells in tissue repair

Immunol Res. 2000;21(2-3):63-9. doi: 10.1385/IR:21:2-3:63.

Abstract

My colleagues and I have a long-term interest in interactions between intraepithelial gammadelta T cells and neighboring epithelial cells. We have focused our studies on interactions in the thymus, skin, and intestine, and are investigating the development, specificity, and function of these gammadelta T cells. Our results have defined unique properties of these cells and support a specialized role for epithelial gammadelta T cells in immune surveillance, wound repair, inflammation, and protection from malignancy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Communication / immunology*
  • Epithelial Cells / immunology*
  • Epithelial Cells / pathology
  • Humans
  • Intestines / immunology
  • Intestines / pathology
  • Receptors, Antigen, T-Cell, gamma-delta / immunology*
  • Regeneration
  • Skin / immunology
  • Skin / pathology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / pathology
  • Thymus Gland / immunology
  • Thymus Gland / pathology
  • Wound Healing

Substances

  • Receptors, Antigen, T-Cell, gamma-delta