Helper T-cell kinetics and investigation of antigen receptor expression on early and memory T-helper cells

Immunology. 1976 Aug;31(2):249-55.


The subcutaneous application of soluble antigen resulted in generation of helper T lymphocytes in the draining lymph nodes, tested 4 days after priming in the adoptive transfer system. Four days later a specific helper T-cell population was detected in the spleen. B-cell activity could be demonstrated 4-5 days after helper T-cell activity in both organs. We investigated the early helper T-cell population and memory T cells with respect to differences in the expression of antigen receptors. No such differences could be detected, either by anti-immunoglobulin-coated Degalan columns or by an antigen-specific rosetting method.

MeSH terms

  • Animals
  • Antibody-Producing Cells
  • Antigens
  • B-Lymphocytes / immunology
  • Binding Sites, Antibody*
  • Female
  • Immunization
  • Immunologic Memory
  • Kinetics
  • Leukocyte Count
  • Male
  • Mice
  • Mice, Inbred CBA
  • Ovalbumin / immunology
  • Receptors, Antigen, B-Cell
  • Serum Albumin, Bovine / immunology
  • T-Lymphocytes / immunology*


  • Antigens
  • Receptors, Antigen, B-Cell
  • Serum Albumin, Bovine
  • Ovalbumin