Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice

Mech Ageing Dev. 2000 May 18;115(1-2):61-71. doi: 10.1016/s0047-6374(00)00109-3.


Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0+/-15.3 and 47.9+/-9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fasting / physiology*
  • Female
  • Killer Cells, Natural / physiology
  • Longevity / physiology*
  • Lymphocyte Culture Test, Mixed
  • Mice
  • Mice, Inbred NZB
  • Mice, Inbred Strains
  • Mitogens / pharmacology
  • Organ Size / physiology
  • Proteinuria / urine
  • Reference Values
  • Survival Analysis
  • Time Factors
  • Weight Gain


  • Mitogens