Modulation of tight junction structure and function by cytokines

Adv Drug Deliv Rev. 2000 Jun 30;41(3):303-13. doi: 10.1016/s0169-409x(00)00048-x.


Dynamic regulation of tight junction function is fundamental to many physiologic processes. Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. Recently, an increasing number of cytokines have been shown to influence tight junction function both in vitro and in vivo. Cytokine-induced effects on tight junction barrier function have also been correlated with effects on intrinsic tight junction proteins and the associated actin cytoskeleton. The aim of this article is to review studies relating to the effects of cytokines on tight junction function and structure.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / pharmacology*
  • Epidermal Growth Factor / pharmacology
  • Hepatocyte Growth Factor / pharmacology
  • Humans
  • Interferon-gamma / pharmacology
  • Tight Junctions / chemistry
  • Tight Junctions / drug effects*
  • Tight Junctions / physiology
  • Transforming Growth Factor beta / pharmacology
  • Tumor Necrosis Factor-alpha / pharmacology


  • Cytokines
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • Epidermal Growth Factor
  • Hepatocyte Growth Factor
  • Interferon-gamma