Transport of fatty acids and metabolites across the peroxisomal membrane

Biochim Biophys Acta. 2000 Jun 26;1486(1):18-27. doi: 10.1016/s1388-1981(00)00045-7.

Abstract

The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. Genetic and biochemical studies in the yeast Saccharomyces cerevisiae have identified enzymes for redox shuttles as well as the first peroxisomal membrane transporter. This peroxisomal ATP-binding cassette transporter (Pat) is highly homologous to the gene mutated in X-linked adrenoleukodystrophy (X-ALD). The yeast Pat is required for import of activated fatty acids into peroxisomes suggesting that this is the primary defect in X-ALD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily D, Member 1
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Acyl Coenzyme A / metabolism
  • Biological Transport
  • Cytoplasm / metabolism
  • Fatty Acids / metabolism*
  • Intracellular Membranes / metabolism*
  • Membrane Proteins / genetics
  • Oxidation-Reduction
  • Peroxisomes / metabolism*
  • Saccharomyces cerevisiae

Substances

  • ABCD1 protein, human
  • ATP Binding Cassette Transporter, Subfamily D, Member 1
  • ATP-Binding Cassette Transporters
  • Acyl Coenzyme A
  • Fatty Acids
  • Membrane Proteins