Evaluation of the short-form 36-item questionnaire to measure health-related quality of life in patients with idiopathic pulmonary fibrosis

Chest. 2000 Jun;117(6):1627-32. doi: 10.1378/chest.117.6.1627.


Objective: To validate the use of the 36-item short-form questionnaire (SF-36) for measuring health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF).

Design: : Observational data at a single point in time.

Setting: : A specialized outpatient respiratory clinic.

Participants: Thirty-four patients (mean +/- SE age, 58.29 +/- 1.87 years) with IPF and no significant comorbidity. A matched control group for HRQL measurements was composed of 34 normal subjects (mean age, 58.00 +/- 1.89 years).

Measurements and results: Dyspnea was measured by the baseline dyspnea index (BDI). Respiratory function evaluation included FVC, FEV(1), and resting arterial blood gases. IPF patients showed a mean BDI score of 5.21 +/- 0.46. The mean FVC and FEV(1) values were 62.41 +/- 2.96% and 66.41 +/- 3.33%, respectively. The mean PaO(2) was 67 +/- 2.51 mm Hg, and the mean PaCO(2) was 37 +/- 1. 05 mm Hg. Patients scored significantly worse than control subjects with respect to the SF-36 domains of physical functioning, physical role, general health perceptions, vitality, social functioning, emotional role, and mental health index. BDI scores were significantly correlated with five SF-36 components, and FVC and FEV(1) were significantly correlated with two SF-36 components. Significant negative correlations were found between arterial pH and four SF-36 domains.

Conclusions: Patients with IPF have a significant impairment of HRQL in both physical and psychological functioning. Dyspnea is the most important factor influencing the quality of life in these subjects. The SF-36 questionnaire is a valid instrument to evaluate HRQL in IPF patients.

MeSH terms

  • Adaptation, Psychological
  • Depression / diagnosis
  • Depression / psychology
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Middle Aged
  • Oxygen / blood
  • Pulmonary Fibrosis / diagnosis
  • Pulmonary Fibrosis / psychology*
  • Quality of Life*
  • Sick Role
  • Sickness Impact Profile*
  • Vital Capacity


  • Oxygen