International comparison of median age at death from cystic fibrosis

Chest. 2000 Jun;117(6):1656-60. doi: 10.1378/chest.117.6.1656.


Study objectives: To compare international trends in mortality from cystic fibrosis.

Design: Comparison of trends in median age at death using national mortality data.

Setting: Data from 10 countries in North America, Europe, and Australasia.

Participants: All persons registered as having died of cystic fibrosis in specified years from 1980 to 1994.

Interventions: Comparison of relative odds of death at the international median age at death for the year of death between countries for two periods of time; from 1980 to 1987 (10 countries) and from 1980 to 1994 (7 countries).

Measurements and results: The international median age at death increased from 8 years in 1974 to 21 years in 1994. Median age at death also increased within all countries, was consistently highest in the United States, and varied significantly by a factor of > twofold between countries. Women were significantly more likely to die at a younger age than the median age at death than men.

Conclusions: Median age at death from cystic fibrosis is increasing, but our findings imply that clinically significant differences in survival with cystic fibrosis persist between countries.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Australia / epidemiology
  • Cause of Death
  • Child
  • Cross-Cultural Comparison*
  • Cystic Fibrosis / mortality*
  • Europe / epidemiology
  • Female
  • Humans
  • Male
  • North America / epidemiology
  • Survival Analysis