Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia

Audiol Neurootol. 2000 May-Aug;5(3-4):207-15. doi: 10.1159/000013882.


Event-related potentials provide an objective index of neurocognitive dysfunction in schizophrenia. Schizophrenia subjects show a decreased mismatch negativity (MMN) amplitude relative to age- and sex-matched controls, along with a characteristic pattern of MMN dysfunction across conditions. Deficits in MMN generation are accompanied by (1) impaired precision of auditory sensory memory performance and (2) an interstimulus-interval-dependent deficit in auditory N(1) generation. Similar deficits are observed following systemic or local infusion of N-methyl-D-aspartate (NMDA) antagonists, supporting glutamatergic and phencyclidine/NMDA models of the disorder. Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Attention / physiology
  • Auditory Cortex / physiopathology*
  • Auditory Perceptual Disorders / physiopathology
  • Contingent Negative Variation / physiology*
  • Evoked Potentials, Auditory / physiology*
  • Glutamic Acid / physiology
  • Humans
  • Prefrontal Cortex / physiopathology
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology


  • Receptors, N-Methyl-D-Aspartate
  • Glutamic Acid