This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2000 Jul;47(1):12-4.

doi: 10.1136/gut.47.1.12.

MMPs in the gut: inflammation hits the matrix

D Schuppan¹, E G Hahn

Affiliations

PMID: 10861255
PMCID: PMC1727957
DOI: 10.1136/gut.47.1.12

Free PMC article

Comment

MMPs in the gut: inflammation hits the matrix

D Schuppan et al. Gut. 2000 Jul.

Free PMC article

. 2000 Jul;47(1):12-4.

doi: 10.1136/gut.47.1.12.

Authors

D Schuppan¹, E G Hahn

Affiliation

¹ Department of Medicine I, Gastroenterology and Hepatology University of Erlangen-Nuernberg, Germany. detlef.schuppan@med1.med.uni-erlangen.de

PMID: 10861255
PMCID: PMC1727957
DOI: 10.1136/gut.47.1.12

No abstract available

PubMed Disclaimer

Figures

Figure 1
Metalloproteinases (MMPs) and their cellular sources in the intestine. Minor or still debated MMP expression is shown in italics. Intestinal fibroblasts appear to play the most prominent role in MMP release during mucosal inflammation and subsequent transformation. Tumour necrosis factor α (TNF-α) has been identified as a major MMP inducing cytokine. Several currently used drugs affect MMP expression and activity indirectly. MMP inhibitors may prove useful in modulating mucosal transformation.

See this image and copyright information in PMC

Comment on

Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease.
Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL. Heuschkel RB, et al. Gut. 2000 Jul;47(1):57-62. doi: 10.1136/gut.47.1.57. Gut. 2000. PMID: 10861265 Free PMC article.
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease.
von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S. von Lampe B, et al. Gut. 2000 Jul;47(1):63-73. doi: 10.1136/gut.47.1.63. Gut. 2000. PMID: 10861266 Free PMC article.

Similar articles

[Matrix metalloproteinases in inflammatory bowel disease - from basic research to clinical significance].
Rath T, Roderfeld M, Graf J, Roeb E. Rath T, et al. Z Gastroenterol. 2009 Aug;47(8):758-69. doi: 10.1055/s-0028-1109520. Epub 2009 Aug 6. Z Gastroenterol. 2009. PMID: 19662589 Review. German.
Role of matrix metalloproteinases in inflammatory bowel disease.
Naito Y, Yoshikawa T. Naito Y, et al. Mol Aspects Med. 2005 Aug-Oct;26(4-5):379-90. doi: 10.1016/j.mam.2005.07.009. Mol Aspects Med. 2005. PMID: 16112187 Review.
[Role of the matrix metalloproteinases activity in inflammatory bowel disease].
Kofla-Dłubacz A, Iwańczak B. Kofla-Dłubacz A, et al. Pol Merkur Lekarski. 2010 Dec;29(174):387-9. Pol Merkur Lekarski. 2010. PMID: 21298991 Review. Polish.
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease.
von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S. von Lampe B, et al. Gut. 2000 Jul;47(1):63-73. doi: 10.1136/gut.47.1.63. Gut. 2000. PMID: 10861266 Free PMC article.
Matrix metalloproteases role in bowel inflammation and inflammatory bowel disease: an up to date review.
OʼShea NR, Smith AM. OʼShea NR, et al. Inflamm Bowel Dis. 2014 Dec;20(12):2379-93. doi: 10.1097/MIB.0000000000000163. Inflamm Bowel Dis. 2014. PMID: 25222664 Review.

See all similar articles

Cited by

Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights.
Kamboj S, Harms C, Wright D, Nash A, Kumar L, Klein-Seetharaman J, Sarkar SK. Kamboj S, et al. Sci Rep. 2022 Apr 6;12(1):5764. doi: 10.1038/s41598-022-09866-7. Sci Rep. 2022. PMID: 35388085 Free PMC article.
Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Ulcerative Colitis.
Chen ZA, Sun YF, Wang QX, Ma HH, Ma ZZ, Yang CJ. Chen ZA, et al. Front Genet. 2021 Jul 9;12:697514. doi: 10.3389/fgene.2021.697514. eCollection 2021. Front Genet. 2021. PMID: 34306038 Free PMC article.
Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of Steroid-Dependent Ulcerative Colitis.
Wang ZY, Qiu BF. Wang ZY, et al. Gastroenterology Res. 2010 Jun;3(3):120-124. doi: 10.4021/gr2010.05.208w. Epub 2010 May 20. Gastroenterology Res. 2010. PMID: 27942289 Free PMC article.
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers.
Cheng HC, Yang HB, Chang WL, Chen WY, Yeh YC, Sheu BS. Cheng HC, et al. ScientificWorldJournal. 2012;2012:539316. doi: 10.1100/2012/539316. Epub 2012 May 1. ScientificWorldJournal. 2012. PMID: 22645431 Free PMC article.
Biologic targeting in the treatment of inflammatory bowel diseases.
Bosani M, Ardizzone S, Porro GB. Bosani M, et al. Biologics. 2009;3:77-97. Epub 2009 Jul 13. Biologics. 2009. PMID: 19707398 Free PMC article. Retracted.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources