Abstract
A highly efficient synthetic method for the trans-tetrahydrofuran (THF) ring building block was established and the title compound was synthesized in 19 steps from trans-1,4-dichloro-2-butene via a convergent route with a Wittig reaction as the key step.
Copyright 2000 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes
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Catalysis
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Chromatography, High Pressure Liquid
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Cyclization
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Ethers
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Furans / chemical synthesis*
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Furans / chemistry
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Glutamates / chemistry
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Lactones / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Ethers
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Furans
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Glutamates
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Lactones
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gigantetracin A