Subglottic stenosis secondary to extramedullary hematopoiesis in a patient with postpolycythemia myeloid metaplasia

Head Neck. 2000 Jul;22(4):435-8. doi: 10.1002/1097-0347(200007)22:4<435::aid-hed17>;2-5.


Background: Extramedullary hematopoiesis (EMH) is known to occur in myeloproliferative disorders and hemoglobinopathies and is usually seen in the spleen and liver.

Methods: We report the first case of EMH causing subglottic stenosis in a woman with postpolycythemia myeloid metaplasia (PPMM). A tracheotomy was performed to maintain the airway and local radiotherapy was given.

Results: Two months after the radiotherapy was completed laryngoscopy showed an unobstructed airway with no evidence of disease, and the patient was successfully decanulated. Magnetic resonance imaging 8 months after radiotherapy confirmed the absence of local disease.

Conclusion: Consideration should be given to EMH as a possible cause of airway obstruction in the differential diagnosis of a patient with a history of PPMM.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Follow-Up Studies
  • Glottis / pathology
  • Glottis / radiation effects
  • Hematopoiesis, Extramedullary* / radiation effects
  • Humans
  • Magnetic Resonance Imaging
  • Polycythemia / complications*
  • Polycythemia / diagnosis
  • Primary Myelofibrosis / complications*
  • Primary Myelofibrosis / diagnosis
  • Tracheal Stenosis / diagnosis
  • Tracheal Stenosis / etiology*
  • Tracheal Stenosis / radiotherapy*
  • Tracheostomy