Bacterial ureases in infectious diseases

Microbes Infect. 2000 Apr;2(5):533-42. doi: 10.1016/s1286-4579(00)00312-9.

Abstract

Ureases are multi-subunit, nickel-containing enzymes that catalyze the hydrolysis of urea to carbon dioxide and ammonia. This brief review discusses the biochemistry and genetics of bacterial ureases and outlines the roles of urea metabolism in microbial ecology and pathogenesis of some of the principle ureolytic species affecting human health.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibody Formation
  • Bacteria / enzymology*
  • Bacteria / genetics
  • Gene Expression Regulation, Enzymologic*
  • Genes, Bacterial
  • Helicobacter / enzymology
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Humans
  • Hydrogen-Ion Concentration
  • Immunity, Cellular
  • Mouth / microbiology
  • Urea / metabolism
  • Urease / genetics*
  • Urease / immunology
  • Urease / metabolism
  • Urinary Tract Infections / microbiology
  • Virulence

Substances

  • Urea
  • Urease