Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis

Ann N Y Acad Sci. 2000 May:902:315-9. doi: 10.1111/j.1749-6632.2000.tb06330.x.

Abstract

We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Arteriosclerosis / blood
  • Arteriosclerosis / physiopathology*
  • Blood Platelets / drug effects
  • Blood Platelets / physiology*
  • Blood Proteins / metabolism
  • Carrier Proteins / blood
  • Carrier Proteins / physiology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology*
  • Humans
  • Leptin / pharmacology*
  • Obesity / blood
  • Obesity / physiopathology*
  • Phosphorylation
  • Platelet Aggregation / drug effects
  • Receptors, Cell Surface*
  • Receptors, Leptin
  • Thrombomodulin / metabolism

Substances

  • Blood Proteins
  • Carrier Proteins
  • LEPR protein, human
  • Leptin
  • Receptors, Cell Surface
  • Receptors, Leptin
  • Thrombomodulin
  • Adenosine Diphosphate