Abstract
A novel tyrosyl tRNA synthetase inhibitor, SB-219383, has been isolated from a Micromonospora sp. The structure of SB-219383 has been elucidated by a combination of derivatisation, spectroscopic and other analytical techniques and found to be N-(L-tyrosyl)-2-amino[1(S*),3(S*),4(S*),5(R*),8(R*)-2,4,5,8-tetrahydroxy -7-oxa-2-azabicyclo[3.2.1]oct-3-y1]acetic acid (1).
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Furans / chemistry*
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Furans / isolation & purification
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Magnetic Resonance Spectroscopy
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Micromonospora
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Molecular Structure
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Structure-Activity Relationship
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Tyrosine-tRNA Ligase / antagonists & inhibitors
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Enzyme Inhibitors
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Furans
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SB 219383
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SB 227871
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Tyrosine-tRNA Ligase