A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1223-6. doi: 10.1016/s0960-894x(00)00219-5.


A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.

MeSH terms

  • Cell Cycle / drug effects*
  • Drug Screening Assays, Antitumor
  • Humans
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology
  • Tumor Cells, Cultured


  • Sulfonamides