Characterization of chromosomal breakpoints in an ALL patient using cross-species color banding

Cancer Genet Cytogenet. 2000 Jun;119(2):118-20. doi: 10.1016/s0165-4608(99)00231-9.


Cross-species color-banded karyotype (Rx-FISH) results were compared with those of conventional G-banded metaphases from the same sample. Breakpoints and karyotype were confirmed as 46,XX,t(8;22)(q24;q11), der(9)t(1;9)(q21;p13) through the novel technology of cross-species color banding in an acute leukemic patient (ALL, L3); the karyotype was 46,XX,t(8;22)(q24;q11),der(9)t(1;9)(q25;p24) by conventional G-banding.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Chromosome Banding / methods*
  • Chromosomes, Human, Pair 1 / ultrastructure
  • Chromosomes, Human, Pair 22 / ultrastructure
  • Chromosomes, Human, Pair 8 / ultrastructure
  • Chromosomes, Human, Pair 9 / ultrastructure
  • Fatal Outcome
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Karyotyping
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Translocation, Genetic