Non-specific viral infections as possible synchronising events of the manifestation of type 1 diabetes

Diabetes Metab Res Rev. May-Jun 2000;16(3):177-8. doi: 10.1002/1520-7560(0000)9999:9999<::aid-dmrr100>;2-5.


Four cases of simultaneous manifestation of Type 1 diabetes in two members of the same household are reported. In all cases, a flu-like infection preceded diabetes onset. Surprisingly, despite simultaneous development of insulin dependency, insulin requirements were strikingly different at 3 months in all cases. These observations suggest that increased insulin resistance during infection may cause insulin deficiency in individuals with widely varying residual beta cell activity.

Publication types

  • Case Reports

MeSH terms

  • Diabetes Mellitus, Type 1 / etiology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / metabolism
  • Female
  • Humans
  • Insulin / administration & dosage
  • Insulin Resistance
  • Male
  • Virus Diseases / complications*


  • Insulin