Is autism a G-alpha protein defect reversible with natural vitamin A?

Med Hypotheses. 2000 Jun;54(6):979-83. doi: 10.1054/mehy.1999.0999.


Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin separates the G-alpha protein from retinoid receptors. Those most at risk report a family history of at least one parent with a pre-existing G-alpha protein defect, including night blindness, pseudohypoparathyroidism or adenoma of the thyroid or pituitary gland. Natural vitamin A may reconnect the retinoid receptors critical for vision, sensory perception, language processing and attention. Autism spectrum disorders have increased from 1 in 10 000 in 1978 to 1 in 300 in some US communities in 1999. Recent evidence indicates that autism is a disorder of the nervous system and the immune system, affecting multiple metabolic pathways.

MeSH terms

  • Autistic Disorder / drug therapy*
  • Autistic Disorder / genetics*
  • Child
  • Choline / therapeutic use
  • GTP-Binding Proteins / genetics*
  • Humans
  • Receptors, Retinoic Acid / antagonists & inhibitors
  • Vitamin A / therapeutic use*


  • Receptors, Retinoic Acid
  • Vitamin A
  • GTP-Binding Proteins
  • Choline