Heterotopic bone formation in two cases of colon carcinoma

Scand J Gastroenterol. 2000 May;35(5):556-8. doi: 10.1080/003655200750023859.


Heterotopic bone formation is rare in the gastrointestinal tract. We here present the clinical and pathologic details of a 56-year-old male patient with mucinous adenocarcinoma of the colon and a 70-year-old male patient with colon metastasis previously operated on for signet-ring-cell carcinoma of the stomach who was treated with radiotherapy postoperatively. Both of them showed diffuse bone metaplasia. Heterotopic bone formation is usually present with mucin-producing benign or malignant tumors. The pathogenesis of osseous metaplasia is not well known; however, it is speculated that the extravasation of mucin may have a stimulatory role.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Mucinous / complications*
  • Aged
  • Carcinoma, Signet Ring Cell / complications*
  • Carcinoma, Signet Ring Cell / secondary
  • Colon / pathology*
  • Colonic Neoplasms / complications*
  • Colonic Neoplasms / secondary
  • Humans
  • Male
  • Metaplasia
  • Middle Aged
  • Ossification, Heterotopic / etiology*
  • Ossification, Heterotopic / pathology