Prevention of neoplastic port site implants in laparoscopy: an experimental study

Surg Laparosc Endosc Percutan Tech. 1999 Aug;9(4):274-8.


Enthusiasm about the application of videolaparoscopy to oncologic diseases has been limited by the growing number of port site implants. Adult Wistar rats were submitted to 6-7 mm Hg carbonic gas pneumoperitoneum. Rats were randomly divided into two groups: group I rats with tumor (200,000 viable cells of Walker tumor) and group 11 rats with no tumor. The pneumoperitoneum was deflated after 30 min. Group I was further randomized into five groups: no treatment; or abdominal irrigation with saline, heparin, chemotherapy (doxorubicin), or chemotherapy associated with heparin. After a period lasting no more than 18 days, the abdominal wall and intraperitoneal organs macroscopically affected were studied histologically. Chemotherapy groups had no port site implants and were significantly different (p < 0.05) than the no treatment, saline, and heparin solution groups, which had incisional implants at frequencies of 100%, 85.7%, and 82.5%, respectively. Intraperitoneal irrigation with chemotherapy solution was effective in preventing incisional implants in this animal model.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Carcinosarcoma / mortality
  • Carcinosarcoma / therapy*
  • Disease Models, Animal
  • Heparin / administration & dosage*
  • Laparoscopy / adverse effects*
  • Male
  • Neoplasm Seeding*
  • Peritoneal Neoplasms / therapy*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Reference Values
  • Survival Analysis
  • Video Recording


  • Antineoplastic Agents
  • Heparin