The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

Immunol Today. 2000 Jul;21(7):348-54. doi: 10.1016/s0167-5699(00)01653-4.


The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen Presentation
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic
  • Gastritis / etiology*
  • Gastritis / immunology*
  • H(+)-K(+)-Exchanging ATPase / immunology*
  • Humans


  • H(+)-K(+)-Exchanging ATPase