Identification, gene structure, and expression of human frizzled-3 (FZD3)

Biochem Biophys Res Commun. 2000 Jun 24;273(1):27-34. doi: 10.1006/bbrc.2000.2882.

Abstract

We report the identification, genomic structure, chromosomal localization, and expression analysis of human frizzled-3 (FZD3), a 7-transmembrane receptor belonging to the frizzled family. The cDNA obtained from adult human brain shows 91% identity at the nucleotide level and 98% at the amino acid level to mouse frizzled-3 (fzd3). The FZD3 locus is located on chromosome 8p21, spans 48 Kb and its coding sequence is distributed in 6 exons intercalated by 5 introns. FZD3 is expressed in all analyzed human tissues, with quantitatively higher expression in the CNS and in urogenital structures.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism
  • Chromosomes, Human, Pair 8 / genetics
  • Cloning, Molecular
  • Exons / genetics*
  • Frizzled Receptors
  • Gene Expression Profiling
  • Humans
  • Introns / genetics*
  • Mice
  • Molecular Sequence Data
  • Neuroblastoma / genetics
  • Organ Specificity
  • Physical Chromosome Mapping
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Receptors, Cell Surface / genetics*
  • Receptors, G-Protein-Coupled*
  • Sequence Alignment
  • Sequence Homology
  • Tumor Cells, Cultured

Substances

  • FZD3 protein, human
  • Frizzled Receptors
  • Fzd3 protein, mouse
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled

Associated data

  • GENBANK/AJ272427