Topographic mapping: organising by repulsion and competition?

Curr Biol. 2000 Jun 15;10(12):R447-51. doi: 10.1016/s0960-9822(00)00530-3.


The establishment of topographic maps of neuronal connections is believed to involve graded repulsion mediated by EphA receptors and ephrin-A ligands. Gene knockouts show that ephrin-A ligands do indeed have a crucial role in mapping, and that mechanisms in addition to graded repulsion must also be at work.

Publication types

  • Review

MeSH terms

  • Animals
  • Ephrin-A3
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Mice
  • Mice, Knockout
  • Synaptic Transmission*


  • Ephrin-A3
  • Membrane Proteins