Transcriptional control: imprinting insulation

Curr Biol. 2000 Jun 15;10(12):R463-5. doi: 10.1016/s0960-9822(00)00534-0.

Abstract

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.

Publication types

  • Review

MeSH terms

  • Animals
  • CCCTC-Binding Factor
  • DNA Methylation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Genomic Imprinting*
  • Insulin-Like Growth Factor II / genetics*
  • Muscle Proteins / genetics*
  • RNA, Long Noncoding
  • RNA, Untranslated*
  • Repressor Proteins*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • Zinc Fingers

Substances

  • CCCTC-Binding Factor
  • DNA-Binding Proteins
  • H19 long non-coding RNA
  • Muscle Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Repressor Proteins
  • Transcription Factors
  • Insulin-Like Growth Factor II