Membrane traffic in polarized epithelial cells

Curr Opin Cell Biol. 2000 Aug;12(4):483-90. doi: 10.1016/s0955-0674(00)00120-4.


Epithelial cells contain apical and basolateral surfaces with distinct compositions. Sorting of certain proteins to the basolateral surface involves the epithelial-specific mu 1b clathrin adaptor subunit. Recent results have shown that targeting to the basolateral surface utilizes the exocyst, whereas traffic to the apical surface uses syntaxin 3. Endocytosis at the apical surface is regulated by ARF6. Transcytosis of IgA is regulated by the p62Yes tyrosine kinase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Membrane / metabolism
  • Cell Polarity
  • Epithelial Cells / metabolism
  • Epithelial Cells / physiology
  • Membrane Fusion
  • Proteins / metabolism*


  • Proteins