Messenger proteins: homeoproteins, TAT and others

Curr Opin Cell Biol. 2000 Aug;12(4):400-6. doi: 10.1016/s0955-0674(00)00108-3.


Some proteins are internalized by live cells by a process that does not involve classical endocytosis and thus gain direct access to the cytoplasm and nucleus. These same proteins are often secreted, despite the absence of a signal peptide. Recent studies of this unexpected mode of intercellular signaling have opened the way for biotechnological developments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Gene Products, tat / metabolism*
  • Homeodomain Proteins / metabolism*
  • Humans
  • Molecular Sequence Data
  • Signal Transduction


  • Gene Products, tat
  • Homeodomain Proteins