Efficacy of anticoagulation in resolving left atrial and left atrial appendage thrombi: A transesophageal echocardiographic study

Am Heart J. 2000 Jul;140(1):150-6. doi: 10.1067/mhj.2000.106648.


Background: Transesophageal echocardiography (TEE) is the gold standard for evaluation of the left atrium and the left atrial appendage (LAA) for the presence of thrombi. Anticoagulation is conventionally used for patients with atrial fibrillation to prevent embolization of atrial thrombi. The mechanism of benefit and effectiveness of thrombi resolution with anticoagulation is not well defined.

Methods and results: We used a TEE database of 9058 consecutive studies performed between January 1996 and November 1998 to identify all patients with thrombi reported in the left atrium and/or LAA. One hundred seventy-four patients with thrombi in the left atrial cavity (LAC) and LAA were identified (1.9% of transesophageal studies performed). The incidence of LAA thrombi was 6.6 times higher than LAC thrombi (151 vs 23, respectively). Almost all LAC thrombi were visualized on transthoracic echocardiography (90.5%). Mitral valve pathology was associated with LAC location of thrombi (P <.0001), whereas atrial fibrillation or flutter was present in most patients with LAA location of thrombi. Anticoagulation of 47 +/- 18 days was associated with thrombus resolution in 80.1% of the patients on follow-up TEE. Further anticoagulation resulted in limited additional benefit.

Conclusions: LAC thrombi are rare and are usually associated with mitral valve pathology. Transthoracic echocardiography is effective in identifying these thrombi. LAA thrombi occur predominantly in patients with atrial fibrillation or flutter. Short-term anticoagulation achieves a high rate of resolution of LAA and LAC thrombi but does not obviate the need for follow-up TEE.

MeSH terms

  • Adult
  • Aged
  • Anticoagulants / therapeutic use*
  • Atrial Fibrillation / complications
  • Atrial Fibrillation / drug therapy*
  • Atrial Function, Left
  • Confidence Intervals
  • Echocardiography
  • Echocardiography, Transesophageal*
  • Female
  • Heart Atria / diagnostic imaging*
  • Heart Atria / physiopathology
  • Heart Diseases / diagnostic imaging
  • Heart Diseases / epidemiology
  • Heart Diseases / etiology
  • Heart Diseases / prevention & control
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Probability
  • Prognosis
  • Registries
  • Retrospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Thromboembolism / diagnostic imaging*
  • Thromboembolism / epidemiology
  • Thromboembolism / etiology
  • Thromboembolism / prevention & control*


  • Anticoagulants