The proximal probe in esophageal pH monitoring: development of a normative database

J Voice. 2000 Jun;14(2):247-54. doi: 10.1016/s0892-1997(00)80033-8.

Abstract

Healthy volunteers without symptoms of either gastroesophageal reflux or laryngopharyngeal reflux and without abnormalities on laryngologic examination were recruited for esophageal pH monitoring. Thirty subjects underwent ambulatory 24-hour double-channel pH probe monitoring to establish normative data for the upper probe, which was positioned just above the upper esophageal sphincter. Data were analyzed excluding meal periods plus 2 minutes of postprandial time. The mean, standard deviation, median, and 95th percentile were calculated for various reflux parameters for the following intervals: total study duration, upright time, supine time, and postprandial time. Normal subjects display physiologic reflux above the upper esophageal sphincter (median one event, 95th percentile 6.9 events), and 80.4% of these events occur in the upright position. The reflux area index (RAI) appears to be the most useful parameter to measure laryngopharyngeal reflux severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Databases as Topic*
  • Esophagogastric Junction / physiology
  • Esophagus / physiology*
  • Female
  • Gastroesophageal Reflux / diagnosis
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Monitoring, Physiologic*
  • Reference Values
  • Severity of Illness Index