Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system

Jpn J Pharmacol. 2000 Apr;82(4):338-42. doi: 10.1254/jjp.82.338.


Recent studies have indicated that sphingosine 1-phosphate (Sph-1-P) is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions. The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model. Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction. Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle. These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via Gi protein, are lacking in the rat heart. Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Blood Pressure / drug effects
  • Cardiovascular System / drug effects*
  • Electrocardiography / drug effects
  • Heart Rate / drug effects
  • Lysophospholipids*
  • Male
  • Myocardium / enzymology
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Sphingosine / analogs & derivatives*
  • Sphingosine / pharmacology*
  • Ventricular Function, Left / drug effects
  • Ventricular Pressure / drug effects


  • Lysophospholipids
  • sphingosine 1-phosphate
  • Adenylyl Cyclases
  • Sphingosine