Fasting, but not adrenalectomy, reduces transport of leptin into the brain

Peptides. 2000 May;21(5):679-82. doi: 10.1016/s0196-9781(00)00195-9.


Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression analysis showed that fasting, but not ADX, significantly decreased the entry of leptin into mouse brain. After 3 days of food deprivation, the influx of leptin became indistinguishable from that of the vascular control (albumin); 5 h of refeeding significantly reversed this reduced rate of influx. Thus, the results indicate that the BBB provides a dynamic site for the regulation of physiological processes involving leptin.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenalectomy*
  • Animals
  • Biological Transport
  • Blood-Brain Barrier
  • Fasting*
  • Leptin / metabolism*
  • Male
  • Mice
  • Mice, Inbred ICR


  • Leptin