Lung function studies in asymptomatic individuals with moderately (Pi SZ) and severely (Pi Z) reduced levels of alpha1-antitrypsin

Scand J Respir Dis. 1976;57(6):267-80.


Extensive physiological evaluation of lung function were conducted in two groups of asymptomatic individuals with deficiencies of alpha1-antitrypsin: seven subjects with phenotype Pi SZ and six subjects with phenotype Pi Z. Four symptomatic individuals of Pi Z type were also investigated. The asymptomatic individuals of both SZ and Z phenotypes revealed reduction of elastic recoil, hypoventilation and hypoperfusion of the lung bases with increased closing and nitogen wash-out volumes. No signs of bronchial obstruction were observed. The asymptomatic Pi SZ subjects revealed as many signs of subclinical disease as did the asymptomatic Pi Z subjects. These data suggest that Pi SZ subjects are at increased risk of emphysema similar to Pi Z subjects.

MeSH terms

  • Adult
  • Bronchitis / physiopathology
  • Dyspnea / physiopathology
  • Expiratory Reserve Volume
  • Female
  • Forced Expiratory Volume
  • Functional Residual Capacity
  • Humans
  • Lung Compliance
  • Lung Volume Measurements
  • Male
  • Maximal Voluntary Ventilation
  • Middle Aged
  • Phenotype
  • Pulmonary Emphysema / physiopathology*
  • Respiration*
  • Smoking / physiopathology
  • Vital Capacity
  • alpha 1-Antitrypsin Deficiency*