AKAP79 and the evolution of the AKAP model

FEBS Lett. 2000 Jun 30;476(1-2):58-61. doi: 10.1016/s0014-5793(00)01671-9.


A molecular explanation for the specificity of the cAMP-dependent protein kinase (PKA) can be provided by its compartmentalization through association with A-kinase-anchoring proteins (AKAPs). Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique subcellular targeting domain. The discovery that AKAPs can bind other signaling enzymes led to the addition of a third property, that of scaffolding molecule. Recent research has now expanded the role of AKAPs to members of multiunit complexes containing both upstream activators and downstream targets.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cell Membrane / physiology
  • Humans
  • Models, Neurological*
  • Neurons / physiology*
  • Signal Transduction*


  • A Kinase Anchor Proteins
  • AKAP5 protein, human
  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins