Serum albumin and colorectal cancer risk

Eur J Clin Nutr. 2000 Jun;54(6):460-2. doi: 10.1038/sj.ejcn.1600997.


Objective: To study the relationship between serum albumin and colorectal cancer occurrence.

Design: A case-control study nested within a cohort followed from 1968 to 1991.

Subjects and methods: The albumin concentration was determined from serum samples stored at -20 degrees C at baseline in 177 incident colorectal cancer cases and 288 controls matched for sex, age and study region.

Results: An elevated risk was present of cancer of the left, distal colon at high serum albumin concentrations. No significant association was observed for the right, proximal colon or the rectum. The relative risks of cancer of the distal and proximal colon among individuals in the highest and lowest quartiles of serum albumin were 17.03 (95% confidence interval 1.48-195) and 0.77 (95% confidence interval 0. 19-3.13), respectively.

Conclusions: The present study lends support to the hypothesis that some dietary factor associated with serum albumin may be a risk factor for distal colon cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Cohort Studies
  • Colonic Neoplasms / blood*
  • Colonic Neoplasms / epidemiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Rectal Neoplasms / blood*
  • Rectal Neoplasms / epidemiology
  • Risk Factors
  • Serum Albumin / analysis*


  • Serum Albumin