Picornavirus RNA translation: roles for cellular proteins

Trends Microbiol. 2000 Jul;8(7):330-5. doi: 10.1016/s0966-842x(00)01788-1.

Abstract

Picornavirus RNA is translated within cells even when cellular cap-dependent protein synthesis is blocked. The efficiency of recognition of the viral RNA by the translational apparatus can determine viral tropism. The roles of cellular translation-initiation factors and other RNA-binding proteins in viral RNA-mediated protein synthesis are discussed.

Publication types

  • Review

MeSH terms

  • 5' Untranslated Regions / genetics
  • Cells, Cultured
  • Humans
  • Picornaviridae / genetics*
  • Picornaviridae / metabolism
  • Protein Biosynthesis*
  • Proteins / metabolism*
  • RNA, Viral / metabolism*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism

Substances

  • 5' Untranslated Regions
  • Proteins
  • RNA, Viral
  • Viral Proteins