Abstract
A roselle (Hibiscus sabdariffa Linn.) tea extract was found to have high inhibitory activity against porcine pancreatic alpha-amylase. Hibiscus acid and its 6-methyl ester were respectively isolated as active principles from the 50% methanol and acetone extracts of roselle tea. The activity of each isolate was compared to that of structurally related citric acid, a previously known inhibitor of fungal alpha-amylase.
MeSH terms
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Animals
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Beverages / analysis*
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Citrates / chemistry
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Citrates / isolation & purification
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Citrates / pharmacology*
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Citric Acid / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Hydrogen-Ion Concentration
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Molecular Structure
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Rosales*
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alpha-Amylases / antagonists & inhibitors*
Substances
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Citrates
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Enzyme Inhibitors
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Citric Acid
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hydroxycitric acid
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alpha-Amylases