Alpha-amylase inhibitors from roselle (Hibiscus sabdariffa Linn.) tea

Biosci Biotechnol Biochem. 2000 May;64(5):1041-3. doi: 10.1271/bbb.64.1041.

Abstract

A roselle (Hibiscus sabdariffa Linn.) tea extract was found to have high inhibitory activity against porcine pancreatic alpha-amylase. Hibiscus acid and its 6-methyl ester were respectively isolated as active principles from the 50% methanol and acetone extracts of roselle tea. The activity of each isolate was compared to that of structurally related citric acid, a previously known inhibitor of fungal alpha-amylase.

MeSH terms

  • Animals
  • Beverages / analysis*
  • Citrates / chemistry
  • Citrates / isolation & purification
  • Citrates / pharmacology*
  • Citric Acid / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Hydrogen-Ion Concentration
  • Molecular Structure
  • Rosales*
  • alpha-Amylases / antagonists & inhibitors*

Substances

  • Citrates
  • Enzyme Inhibitors
  • Citric Acid
  • hydroxycitric acid
  • alpha-Amylases