Regiospecific carbonylative annulation of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladium-thiourea-dppp complex

Org Lett. 2000 Jun 15;2(12):1765-8. doi: 10.1021/ol000087t.

Abstract

[reaction: see text] Regiospecific carbonylative annulation of o-iodophenol acetates and acetylenes mediated by palladium-thiourea-dppp complex in the presence of base at 40 degrees C under a balloon pressure of CO generates diversified flavones in high yields. This newly developed synthetic technology provides a highly efficient method for potential application to the combinatorial synthesis of those heterocycles on the solid support.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylene / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Flavonoids / chemical synthesis
  • Flavonoids / chemistry*
  • Palladium / chemistry*
  • Phenols / chemistry
  • Thiourea / chemistry

Substances

  • Flavonoids
  • Phenols
  • Palladium
  • Thiourea
  • Acetylene