Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease

Circulation. 2000 Jul 4;102(1):21-7. doi: 10.1161/01.cir.102.1.21.

Abstract

Background: Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed.

Methods and results: In a double-blind trial, 3090 patients with a previous myocardial infarction or stable angina, total cholesterol of 180 to 250 mg/dL, HDL-C < or =45 mg/dL, triglycerides < or =300 mg/dL, and low-density lipoprotein cholesterol < or =180 mg/dL were randomized to receive either 400 mg of bezafibrate per day or a placebo; they were followed for a mean of 6.2 years. The primary end point was fatal or nonfatal myocardial infarction or sudden death. Bezafibrate increased HDL-C by 18% and reduced triglycerides by 21%. The frequency of the primary end point was 13. 6% on bezafibrate versus 15.0% on placebo (P=0.26). After 6.2 years, the reduction in the cumulative probability of the primary end point was 7.3%, (P=0.24). In a post hoc analysis in the subgroup with high baseline triglycerides (> or =200 mg/dL), the reduction in the cumulative probability of the primary end point by bezafibrate was 39.5% (P=0.02). Total and noncardiac mortality rates were similar, and adverse events and cancer were equally distributed.

Conclusions: Bezafibrate was safe and effective in elevating HDL-C levels and lowering triglycerides. An overall trend in a reduction of the incidence of primary end points was observed. The reduction in the primary end point in patients with high baseline triglycerides (> or =200 mg/dL) requires further confirmation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Apolipoprotein A-I / biosynthesis
  • Apolipoprotein A-II / biosynthesis
  • Apolipoprotein C-III
  • Apolipoproteins C / biosynthesis
  • Bezafibrate / administration & dosage*
  • Bezafibrate / adverse effects
  • Cholesterol, HDL / blood*
  • Coronary Disease / blood
  • Coronary Disease / drug therapy*
  • Coronary Disease / mortality
  • Coronary Disease / prevention & control*
  • Female
  • Fibrinogen / metabolism
  • Follow-Up Studies
  • Humans
  • Hypolipidemic Agents / administration & dosage*
  • Hypolipidemic Agents / adverse effects
  • Lipoprotein Lipase / metabolism
  • Male
  • Middle Aged
  • Survival Analysis
  • Treatment Outcome
  • Triglycerides / blood*

Substances

  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Apolipoprotein C-III
  • Apolipoproteins C
  • Cholesterol, HDL
  • Hypolipidemic Agents
  • Triglycerides
  • Fibrinogen
  • Lipoprotein Lipase
  • Bezafibrate