Primary mediastinal choriocarcinoma in a man

Chest. 1975 Jan;67(1):106-8. doi: 10.1378/chest.67.1.106.

Abstract

Choriocarcinoma with a primary site in the chest is rarely found. Characteristically, it is seen in young men presenting with cough, gynecomastia and chest pain. The disease is invariably fatal. The presently accepted therapy (triple therapy), consisting of methotrexate, actinomycin D and chlorambucil, has been unsuccessful to date.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Choriocarcinoma* / diagnosis
  • Choriocarcinoma* / drug therapy
  • Cyclophosphamide / therapeutic use
  • Dactinomycin / therapeutic use
  • Humans
  • Leucovorin / therapeutic use
  • Male
  • Mediastinal Neoplasms* / diagnosis
  • Mediastinal Neoplasms* / drug therapy
  • Methotrexate / therapeutic use
  • Vincristine / therapeutic use

Substances

  • Dactinomycin
  • Vincristine
  • Cyclophosphamide
  • Leucovorin
  • Methotrexate