CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells

Nat Immunol. 2000 Jul;1(1):83-7. doi: 10.1038/76957.


The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+ subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.

MeSH terms

  • Animals
  • Antigens, Protozoan / immunology
  • CD8 Antigens / immunology*
  • Dendritic Cells / immunology*
  • Immunity, Cellular
  • Interleukin-12 / immunology*
  • Mice
  • Receptors, CCR5 / immunology*
  • Signal Transduction / immunology
  • Toxoplasma / immunology*
  • Toxoplasmosis / immunology*


  • Antigens, Protozoan
  • CD8 Antigens
  • Receptors, CCR5
  • Interleukin-12