Apolipoprotein E and atherosclerosis

Curr Opin Lipidol. 2000 Jun;11(3):243-51. doi: 10.1097/00041433-200006000-00004.


Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apolipoproteins E / physiology*
  • Arteriosclerosis / physiopathology*
  • Cholesterol / blood
  • Homeostasis
  • Humans
  • Inflammation / blood


  • Apolipoproteins E
  • Cholesterol