Epidemiology and pathogenesis of Neisseria meningitidis

Microbes Infect. 2000 May;2(6):687-700. doi: 10.1016/s1286-4579(00)00356-7.


Neisseria meningitidis, an exclusive pathogen of humans, remains the leading worldwide cause of meningitis and fatal sepsis, usually in otherwise healthy individuals. In recent years, significant advances have improved our understanding of the epidemiology and genetic basis of meningococcal disease and led to progress in the development of the next generation of meningococcal vaccines. This review summarizes current knowledge of the human susceptibility to and the epidemiology and molecular pathogenesis of meningococcal disease.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Disease Susceptibility
  • Humans
  • Meningitis, Meningococcal / epidemiology*
  • Meningitis, Meningococcal / microbiology*
  • Meningococcal Infections / epidemiology*
  • Meningococcal Infections / microbiology*
  • Neisseria meningitidis / pathogenicity*
  • Virulence