Ophthalmologic complications after intraoral local anesthesia with articaine

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Jul;90(1):21-4. doi: 10.1067/moe.2000.107506.


A series of 14 cases of ophthalmologic complications after intraoral anesthesia of the posterior superior alveolar nerve is presented. The most commonly encountered symptoms were diplopia, mydriasis, palpebral ptosis, and abduction difficulties of the affected eye. In all cases, these effects occurred a few minutes after injection of the anesthetic, followed by complete resolution without sequelae on cessation of the anesthetic effect. The pathogenic mechanism underlying such ophthalmologic disorders is discussed in terms of a possible diffusion of the anesthetic solution toward the orbital region.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Anesthesia, Dental / adverse effects*
  • Anesthetics, Local / adverse effects*
  • Blepharoptosis / chemically induced
  • Carticaine / adverse effects*
  • Diplopia / chemically induced
  • Eye Diseases / chemically induced*
  • Female
  • Horner Syndrome / chemically induced
  • Humans
  • Injections / adverse effects
  • Male
  • Maxillary Nerve
  • Middle Aged
  • Mydriasis / chemically induced
  • Ocular Motility Disorders / chemically induced


  • Anesthetics, Local
  • Carticaine