Sarcoma After Radiation Therapy: Retrospective Multiinstitutional Study of 80 Histologically Confirmed Cases. Radiation Therapist and Pathologist Groups of the Fédération Nationale Des Centres De Lutte Contre Le Cancer

Radiology. 2000 Jul;216(1):197-205. doi: 10.1148/radiology.216.1.r00jl02197.

Abstract

Purpose: To evaluate the best strategy for treatment of sarcoma that occurs after radiation therapy.

Materials and methods: Records were retrospectively reviewed for 80 patients with a confirmed histologic diagnosis of sarcoma that occurred after radiation therapy performed during 1975-1995. The patients were treated for breast cancer (n = 33, 42%), non-Hodgkin lymphoma (n = 9, 11%), cervical cancer (n = 9, 11%), benign lesions (n = 4, 5%), or other tumors (n = 25, 31%). Sarcoma occurred after a mean latency of 12 years (range, 3-64 years), with most (70%) developing in the soft tissue. Treatment included surgery (28 patients), surgery and chemotherapy (18 patients), chemotherapy only (15 patients), and radiation therapy (14 patients).

Results: By the end of the study, 51 patients were dead, including 46 due to sarcoma. Median survival was 23 months. Overall survival rates at 2 and 5 years, respectively, were 69% and 39% for patients treated with surgery, 10% and 0% for those treated with chemotherapy, and 52% and 35% for those treated with surgery and chemotherapy (P =.001). The 2- and 5-year rates for survival without recurrence were 54% and 32%, respectively.

Conclusion: The results confirm the beneficial effect of surgery. Further study is needed to explore the roles of combined treatments.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Radiation-Induced*
  • Prognosis
  • Radiotherapy / adverse effects*
  • Retrospective Studies
  • Sarcoma / etiology*
  • Sarcoma / mortality
  • Sarcoma / therapy
  • Survival Rate