B-mode enhancement at phase-inversion US with air-based microbubble contrast agent: initial experience in humans

Radiology. 2000 Jul;216(1):273-8. doi: 10.1148/radiology.216.1.r00jl27273.


Pulse- or phase-inversion ultrasonography (US) sums the signals returned from two 180 degrees ultrasound pulses. Linear scattering from tissue results in a signal void while nonlinear signals from microbubbles stand out. The technique was applied with a US contrast agent in 39 human subjects. B-mode enhancement of vessels and organ parenchyma was seen in all cases. Enhancement occurred from flowing and stationary microbubbles. The flow-independent enhancement of normal and abnormal tissue represents a major advance in contrast material-enhanced US with many potential applications especially in tumor imaging.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media*
  • Female
  • Humans
  • Male
  • Microspheres
  • Middle Aged
  • Polysaccharides*
  • Ultrasonography / methods*


  • Contrast Media
  • Polysaccharides
  • SHU 508