Notch signal transduction: a real rip and more

Curr Opin Genet Dev. 2000 Aug;10(4):363-9. doi: 10.1016/s0959-437x(00)00097-6.


The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Endopeptidases / metabolism
  • Ligands
  • Membrane Proteins / metabolism*
  • Presenilin-1
  • Receptors, Notch
  • Signal Transduction / physiology*


  • Ligands
  • Membrane Proteins
  • Presenilin-1
  • Receptors, Notch
  • Endopeptidases