Stepwise specification of lymphocyte developmental lineages

Curr Opin Genet Dev. 2000 Aug;10(4):370-9. doi: 10.1016/s0959-437x(00)00098-8.

Abstract

B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Cell Differentiation
  • Cell Lineage
  • DNA-Binding Proteins / metabolism
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Membrane Proteins / physiology
  • PAX5 Transcription Factor
  • Proteins / metabolism
  • Receptors, Notch
  • T-Lymphocytes / cytology*
  • Thymus Gland / cytology
  • Trans-Activators / metabolism
  • Transcription Factors*

Substances

  • DNA-Binding Proteins
  • EBF1 protein, human
  • Membrane Proteins
  • PAX5 Transcription Factor
  • PAX5 protein, human
  • Proteins
  • Receptors, Notch
  • Trans-Activators
  • Transcription Factors