Hypopyon after repeated transplantation of human amniotic membrane onto the corneal surface

Ophthalmology. 2000 Jul;107(7):1344-6. doi: 10.1016/s0161-6420(00)00167-6.


Objective: The authors describe a localized probable immunoreaction after repeated transplantation of amniotic membrane (AM) onto the corneal surface.

Design: Interventional case report.

Intervention: Amniotic membrane was transplanted onto the corneal surface of a 78-year-old female with a deep trophic corneal ulcer resulting in temporary epithelial closure. A second and finally third amniotic membrane transplantation (AMT) was performed because of recurrent ulcerations. All three AMs were obtained from the same donor.

Results: The first transplantation of the AM was without complication. However, a hypopyon developed 2 days after the second and 2 days after the third AMT, but the patient responded immediately to topical and systemic corticosteroids.

Conclusions: Immunologic, toxic, and hypersensitivity effects could have contributed to the hypopyon iritis that appeared after the second and third AMT, but not after the initial transplantation. In case of a repeated AMT, the use of AM from different donors may help to minimize the risk of an immediate postoperative intraocular inflammation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amnion / transplantation*
  • Anterior Chamber / drug effects
  • Anterior Chamber / pathology*
  • Anti-Bacterial Agents / therapeutic use
  • Corneal Ulcer / surgery*
  • Eye Diseases / drug therapy
  • Eye Diseases / etiology*
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Postoperative Complications* / drug therapy
  • Reoperation
  • Suppuration / drug therapy
  • Suppuration / etiology


  • Anti-Bacterial Agents
  • Glucocorticoids