Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

Mol Psychiatry. 2000 Jul;5(4):350-6. doi: 10.1038/sj.mp.4000721.


This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / antagonists & inhibitors
  • Humans
  • Mental Disorders / chemically induced
  • Mental Disorders / drug therapy*
  • Psychiatry / trends*
  • Pulse Therapy, Drug / trends*


  • Antipsychotic Agents