Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers

Oral Oncol. 2000 Jan;36(1):42-6. doi: 10.1016/s1368-8375(99)00048-2.

Abstract

We investigated 191 patients with oral cancer (121 males and 70 females) and 121 non oral cancer patients (69 males and 52 females), both groups with a history of alcohol use. Blood was analyzed with aldehyde dehydrogenase 2 (ALDH 2) and glutathione S-transferase M 1 (GSTM 1) genotyping. ALDH 2 genotyping was performed by polymerase chain reaction (PCR)-Restriction fragment length polymorphism (RFLP) method and GSTM 1 genotyping was amplified with PCR using GSTM 1 specific primers. In the oral cancer group, the alcohol-drinking rate (59.7%) was significantly higher than in the non cancer group (alcohol-drinking rate 27.3%, p < 0.01). The incidence of inactive ALDH 2 and GSTM 1 in the cancer group with an alcohol-drinking habit was 34.2 and 67.5% and was higher than in the non cancer group with an alcohol-drinking habit (15.1, 45.5%).

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / adverse effects
  • Aldehyde Dehydrogenase / blood*
  • Aldehyde Dehydrogenase / genetics
  • Carcinoma, Squamous Cell / enzymology*
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / genetics
  • Female
  • Glutathione Transferase / blood*
  • Glutathione Transferase / genetics
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Mouth Neoplasms / enzymology*
  • Mouth Neoplasms / epidemiology
  • Mouth Neoplasms / genetics
  • Neoplasm Proteins / blood*
  • Neoplasm Proteins / genetics
  • Odds Ratio
  • Risk Factors

Substances

  • Neoplasm Proteins
  • Aldehyde Dehydrogenase
  • Glutathione Transferase