Pyridoxine therapy in a patient with severe hydrazine sulfate toxicity

Crit Care Med. 2000 Jun;28(6):2116-8. doi: 10.1097/00003246-200006000-00076.


Objective: To report hydrazine sulfate as a cause of severe encephalopathy and to report its response to high-dose pyridoxine therapy.

Design: Case report.

Setting: An adult six-bed medical/surgical intensive care unit of a general hospital.

Patient: One patient who developed severe encephalopathy after hydrazine sulfate.

Intervention: 5 g i.v. pyridoxine.

Measurements and main results: After 180 mg/day for 2 wks followed by 360 mg/day of hydrazine sulfate ingestion, our patient suffered severe encephalopathy. He received mechanical ventilation with attendant supportive measures and high-dose pyridoxine. The patient's encephalopathy resolved 24 hrs after receiving pyridoxine.

Conclusion: Severe encephalopathy could result from hydrazine sulfate toxicity. High-dose pyridoxine is an effective treatment to reverse this encephalopathy.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / poisoning*
  • Brain Diseases / chemically induced*
  • Brain Diseases / drug therapy*
  • Humans
  • Hydrazines / poisoning*
  • Male
  • Middle Aged
  • Pyridoxine / therapeutic use*
  • Severity of Illness Index


  • Antineoplastic Agents
  • Hydrazines
  • hydrazine
  • Pyridoxine